ORLANDO, Fla., Oct. 15, 2026 /PRNewswire/ -- NICHOLAS AIR is pleased to announce its participation in the 2026 RTAG National Convention at the Orange County Convention Center in Orlando, FL.

The world's largest veteran aviation charity, RTAG helps United States service members of all experience levels launch civilian careers in flight operations, maintenance, and technical disciplines. RTAG connects leading corporate partners with the country's largest network of veteran aviation professionals.

NICHOLAS AIR's presence at this year's RTAG National Convention reflects the respect and deep gratitude the company has for our country's service members. Veterans play an essential role across our flight operations and are among our top Pilots and maintenance personnel who make safety their first priority, delivering the premium experience that we are known for. NICHOLAS AIR is committed to providing premier career pathways for military veterans while honoring the dedication and skill that they bring to private aviation.

"RTAG has built a reputation in the industry as one of the most respected and talked about events, and we are excited to exhibit for the first time this year. From veterans to pilots and aviation professionals looking to launch their career, this event brings a community together that is united in their passion for aviation," said Abby Carlton, Director of Recruitment. "At NICHOLAS AIR, we are always committed to connecting with and hiring the best aviators, and we can't wait to start building those relationships at RTAG this week."

Attendees will have the opportunity to engage with NICHOLAS AIR staff where representatives will be on hand to discuss career paths, pilot development, and the career benefits of being part of the flight line at NICHOLAS AIR. The event helps to bridge the gap between military flight training and a possible career in luxury private aviation.

About NICHOLAS AIR

NICHOLAS AIR is the Standard of private aviation in the United States, distinguished by owning and operating the industry's most exclusive fleet for its national Members. For nearly 30 years, the company has remained true to an authentic heritage built on uncompromising quality, consistency, and trust—delivering an elevated private travel experience for its Private Jet Card Members and Fractional Owners. Every day, every flight, NICHOLAS AIR continues to define the premium standard of Part 135 operators.

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DELRAY BEACH, Fla., Oct. 15, 2026 /PRNewswire/ -- According to MarketsandMarkets™, the Rolling Stock Market is estimated to grow from USD 31.69 billion in 2026 to USD 43.74 billion in 2033, at a CAGR of 4.7%.

Browse 240 market data Tables and 65 Figures spread through 400 Pages and in-depth TOC on "Rolling Stock Market"

Rolling Stock Market Size & Forecast:

- Market Size Available for Years: 2022-2033

- 2026 Market Size: USD 31.69 Billion

- 2033 Projected Market Size: USD 43.74 Billion

- CAGR (2026–2033): 4.7%

Rolling Stock Market Trends & Insights:

- Rapid transit expansion and fleet modernization are increasing the demand for metro rolling stock.

- Conventional locomotives are supporting established freight and regional applications.

- Europe drives electro-diesel locomotive demand through fleet renewal and route flexibility.

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The rolling stock market is driven by the expansion and modernization of both passenger and freight rail networks. Urbanization and the rising demand for mass transportation are fueling investments in rapid transit and passenger rolling stock. At the same time, increased freight rail activity is driving demand for higher-capacity, more efficient locomotives and wagons.

In India, Indian Railways transported 7.41 billion passengers during fiscal year 2025–2026, up 3.54%. Freight loading also reached a record 1,670 million tons, up 3.25%. Urbanization and growing transportation demands continue to support investments in rapid transit and passenger rolling stock, while freight activity drives the need for higher-capacity locomotives and wagons. Additionally, initiatives for fleet replacement, electrification, and improved energy efficiency are driving demand for electric and electro-diesel locomotives. These factors are expected to sustain market growth through 2033.

For example, in 2024, trains accounted for 7.5% of total passenger kilometers in the EU, an increase from 7.2% in 2023. This marked the first time since 2014 that trains surpassed buses, coaches, and trolleybuses in passenger transport. Rail's share of passenger transport increased by 0.9 percentage points compared to 2014. This rise in rail passenger usage is driving continued demand for metro trains, regional trains, commuter trains, and intercity rolling stock, particularly in countries with high rail utilization such as Hungary, Austria, and the Netherlands.

Rolling Stock Fleet Modernization and Rail Capacity Expansion Support Demand

- Rail operators are investing in fleet modernization to replace aging rolling stock and improve reliability, passenger capacity, energy efficiency, and lifecycle performance across passenger and freight applications. For instance, in September 2026, Alstom and TransPennine Express signed contracts worth more than USD 1.4 billion, including around USD 1.09 billion for 29 battery-electric trainsets. The contract reflects growing investment in fleet renewal through battery-electric and more energy-efficient rolling stock.

- Expansion of urban rail and rapid transit systems is supporting demand for passenger rolling stock as cities seek higher-capacity transportation solutions. In FY 2025/26, Alstom recorded USD 16.7 billion in stock orders, compared with USD 8.80 billion in the previous fiscal year. The company reported orders across Europe, the Americas, and Asia/Pacific. The order growth indicates stronger procurement activity as operators accelerate fleet renewal and invest in higher-capacity, technology-enabled passenger rolling stock.

- Electrification of railway networks is supporting the adoption of electric locomotives, while diesel and electro-diesel locomotives remain relevant on routes with limited electrification coverage. In July 2026, Siemens Mobility signed an approximately EUR 3 billion (approximately USD 3.5 billion) contract with Italo Holding for 26 Velaro high-speed trains, with an option for 14 additional trains and a 30-year service agreement. The contract highlights continued investment in high-speed trainsets to increase passenger capacity and strengthen long-term fleet performance.

- Freight transportation supports demand for locomotives and wagons with higher hauling capacity and improved operating efficiency. Recent rolling stock procurement also includes high-capacity electric traction. In India, Siemens has been advancing the deployment of 9,000 HP electric freight locomotives to support higher-capacity freight operations.

Rail operators and rolling stock manufacturers are prioritizing fleet modernization as a crucial strategy to enhance passenger capacity, freight efficiency, reliability, and energy performance. Aging fleets still require replacement, while new metro procurement initiatives—such as Alstom's Line 18 trainsets in France and various metro car orders in the US—are driving demand for new passenger rolling stock. Additionally, dedicated freight corridor programs and cross-border freight operations are promoting the acquisition of modern locomotives and freight wagons, including Siemens Vectron locomotives for European freight operators.

As electrification expands, electric locomotives are gaining prominence; however, diesel and electro-diesel locomotives remain important for routes where electrification is limited. Thus, the near-term market is influenced by fleet replacement, metro train procurement, demand for freight locomotives and wagons, and the adoption of electric and alternative-propulsion rolling stock, rather than a single technological transition.

Rapid transit expansion and fleet modernization are increasing the demand for metro rolling stock.

Rapid transit trains are becoming increasingly important as cities expand their urban rail networks to tackle rising traffic congestion, reduce carbon emissions, and promote economic growth. Investment in new metro and regional rapid transit systems is driving the demand for modern trainsets that offer higher passenger capacity, improved energy efficiency, and reliable operations.

For example, in August 2026, India's Ministry of Railways announced plans to manufacture 238 AC EMU rakes for Mumbai's suburban railway, with production scheduled to begin in 2027 and the complete order expected to be fulfilled by 2030.

The adoption of advanced propulsion, train control, and automated operating technologies is also shaping rolling stock procurement. Operators are increasingly focusing on automated operations and enhanced safety features, which include automatic train control, real-time monitoring, driver assistance, and onboard diagnostic systems. Smart onboard technologies are also improving passenger information, connectivity, accessibility, and the overall travel experience.

In June 2026, Siemens received an order from Titagarh Rail Systems to supply propulsion systems and Train Control and Monitoring Systems for 12 trains for the Pune Metro extension. Furthermore, Alstom's 52 Movia metro trainsets entered revenue service in September 2026 as part of the latest phase of the Indore Metro, with all trains manufactured in India.

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Conventional locomotives are supporting established freight and regional applications.

Conventional locomotives remain essential for freight and regional rail operations, particularly where operators depend on reliable propulsion systems for established routes and conditions. Demand for these locomotives is driven by fleet replacement, heavy-haul operations, and continued use on routes where existing traction configurations remain effective. Manufacturers are enhancing conventional locomotives with upgraded traction performance, improved fuel efficiency, advanced braking systems, and better onboard monitoring and control technologies. These enhancements aim to improve locomotive performance without necessitating a complete transition to alternative propulsion systems.

The market for conventional locomotives is projected to grow from USD 9.12 billion in 2025 to USD 11.92 billion by 2033, reflecting a 3.4% CAGR. This moderate growth rate indicates a mature market; however, the substantial existing fleet and ongoing replacement needs continue to ensure a stable revenue base. As a result, conventional locomotives remain crucial for manufacturers serving established freight and regional markets, even as battery, hydrogen, and dual-mode technologies are being explored in select applications.

Europe drives electro-diesel locomotive demand through fleet renewal and route flexibility.

Europe is an important market for electro-diesel and dual-mode locomotives, as freight and passenger services operate on both electrified and non-electrified routes. This has created demand for locomotives that can seamlessly switch between electric and diesel traction without changing locomotives. A key example is Stadler's EURODUAL, which combines electric and diesel traction on a single platform. This locomotive supports freight operations in Germany, Austria, France, Belgium, Norway, Sweden, and Turkey. In April 2026, Stadler also received approval for EURODUAL operations in Slovenia, Croatia, and Serbia, further extending its reach across Central and Southeast Europe.

Interest is growing in more flexible and efficient locomotive platforms. Stadler has delivered EURODUAL locomotives to various European freight operators, including Havelländische Eisenbahn in Germany, where they operate on both electrified and non-electrified routes. This design lets operators avoid changing locomotives when transitioning between different traction environments, enhancing operational flexibility in freight services.

Technology is also evolving to include battery-supported propulsion. For instance, in 2025, NEXRAIL ordered up to 200 EURO9000 panto battery hybrid locomotives from Stadler.

Nyobolt's Battery Technology Enables Digit 5 to Work More Than 20 Hours in a 24-hour Day

SALEM, Ore. and CAMBRIDGE, United Kingdom, Oct. 15, 2026 /PRNewswire/ -- Agility Robotics, a leading humanoid robotics and physical AI company, today announced that Nyobolt, a pioneer of high-power, ultra-fast charging solutions, is the technology provider to Agility. The technology powers one of Digit® 5's most significant upgrades: a fast recharge battery system that enables Digit to work more than 20 hours in a 24-hour day.

Agility recently unveiled Digit 5 as its first humanoid robot designed for cooperatively safe work at scale, allowing it to work in close proximity to people. As part of its upgrades, Digit 5 will feature a new battery system that delivers 90-minutes of runtime and charges in just 9 minutes, achieving a 10:1 run-to-charge ratio, up from Digit 4's 2:1 ratio. This rapid charge capability is designed to keep Digit working, enabling more than two shifts in a single day and helping customers get more from each robot.

"For our customers, Digit's uptime is the business case," said Daniel Diez, Chief Business Officer of Agility Robotics. "Digit 5 will deliver more than 20 hours of productive work in a 24-hour day, more than two full shifts. That's the kind of gain that materially improves the value customers get from Digit and the economics of deploying a humanoid robot fleet. Nyobolt's ultra-fast charging technology gets us there, and it's one of the pieces that makes Digit 5 ready for full-scale operation."

Nyobolt's unique high-power battery technology is built for demanding industrial conditions, combining fast charging, exceptional cycle life, and reduced system weight. By removing the power bottleneck that has historically constrained autonomous robot fleet economics, the system addresses a key constraint on robot utilization: downtime. The result is a compelling potential advantage for Digit 5 customers, who can target longer operating windows, more productive shifts and more demanding task sequences. Combined with Agility's experience deploying humanoid robots in real commercial environments, this battery performance is designed to strengthen Digit's value proposition for warehouse, distribution and manufacturing operations.

"Nyobolt's technology was chosen because Digit 5 will need more power from a smaller, lighter pack, in environments where reliability isn't optional," said Sai Shivareddy, Co-founder and CEO at Nyobolt. "Agility set an exceptionally high bar for what a battery has to withstand in live warehouse and manufacturing environments, and this partnership shows what's possible when ultra-fast charging is engineered for the toughest conditions in physical AI."

Early access to Digit 5 equipped with Nyobolt's battery technology is expected to begin in the first half of 2027, with increasing availability over the following six to nine months for manufacturing, warehouse and distribution operators.

Agility is preparing to become a public company through its previously announced business combination with Churchill Capital Corp XI (Nasdaq: CCXI) ("Churchill XI"). The business combination is expected to close in the fourth quarter of 2026, after which the combined company will operate as Agility Robotics and is expected to trade on Nasdaq under the ticker symbol "AGLT."

About Agility Robotics

Headquartered in Salem, Oregon, with offices in Pittsburgh, Pennsylvania and Fremont, California, Agility Robotics' mission is to build robot partners that augment the human workforce. Agility's groundbreaking general-purpose humanoid robot, Digit, is the first multi-purpose, human-centric robot that is Made for Work® and commercially deployed today. With more than 65,000 hours of real-world operation combined with industry-leading safety standards, we're pioneering a new era of automation that enhances human potential. To learn more, visit agilityrobotics.com.

Agility, the Agility logo, Digit, Agility Arc, RoboFab, and Made for Work are trademarks of Agility Robotics, Inc. All rights reserved. Third-party trademarks are the property of their respective owners.

About Nyobolt

Nyobolt is a pioneer in high-power, fast-charging energy solutions that deliver mission-critical uptime for power-demanding industries. Founded in 2019, the company is leading the Instant Power revolution by combining proprietary anode materials, advanced battery cell design, and integrated power electronics to unlock ultrafast charging, exceptional power density, and extended lifecycle.

With a robust patent portfolio and a global footprint, Nyobolt unlocks next-gen industrial performance across AI datacenters, Physical AI applications (Robotics & Humanoids), and mobility applications. Its solutions reduce total cost of ownership while meeting the performance and reliability demands of an always-on world. For more information, please visit www.nyobolt.com.

About Churchill Capital Corp XI

Churchill XI is a blank check company formed for the purpose of effecting a merger, amalgamation, share exchange, asset acquisition, share purchase, reorganization or similar business combination with one or more businesses. It may pursue an initial business combination target in any business or industry.

Additional Information About the Proposed Transaction and Where to Find It

The proposed transaction will be submitted to shareholders of Churchill XI for their consideration. Churchill XI and Agility have jointly filed a registration statement on Form S-4 (the "Registration Statement") with the Securities and Exchange Commission (the "SEC"), which was declared effective by the SEC on October 13, 2026, and which includes a definitive proxy statement/prospectus. The definitive proxy statement/prospectus and other relevant documents have been distributed to Company stockholders and Churchill XI shareholders as of September 14, 2026, the record date established for voting on the proposed transaction, in connection with Churchill XI's solicitation of proxies for the vote by Churchill XI's shareholders in connection with the proposed transaction and other matters described in the Registration Statement, as well as the prospectus relating to the offer of the securities to be issued to Company stockholders in connection with the completion of the proposed transaction. Before making any voting or investment decision, Churchill XI and Agility stockholders and other interested persons are advised to read the definitive proxy statement/prospectus, as well as other documents filed with the SEC by Churchill XI in connection with the proposed transaction, as these documents contain important information about Churchill XI, the Company and the proposed transaction. Shareholders may obtain a copy of the definitive proxy statement/prospectus as well as other documents filed by Churchill XI with the SEC, without charge, at the SEC's website located at www.sec.gov or by directing a written request to Churchill Capital Corp XI, 640 Fifth Avenue, 14th Floor, New York, NY 10019.

Forward-Looking Statements

This press release includes "forward-looking statements" within the meaning of the federal securities laws. Forward-looking statements may be identified by the use of words such as "estimate," "plan," "project," "forecast," "intend," "will," "expect," "anticipate," "believe," "seek," "target," "continue," "could," "may," "might," "possible," "potential," "predict," "should," "would" or similar expressions that predict or indicate future events or trends or that are not statements of historical matters, but the absence of these words does not mean that a statement is not forward-looking. We have based these forward-looking statements on current expectations and projections about future events. These statements include statements relating to, without limitation: the expected performance and capabilities of Digit 5 and its battery system, including expected runtime, recharge time, run-to-charge ratio, operating hours in a 24-hour day and ability to support multiple shifts; the expected benefits of Nyobolt's battery technology, including with respect to charging speed, cycle life, system weight, robot uptime and utilization, and fleet economics; the anticipated benefits of the Company's relationship with Nyobolt, including the exclusive nature of such relationship; the expected timing of early access to, and broader commercial availability of, Digit 5; estimates of customer adoption rates, market acceptance and usage patterns; the timing and success of the Company's future development plans; the ability of the Company to implement its strategic initiatives and continue to innovate its existing products and services; expectations regarding the Company's ability to attract, retain and expand its customer base; the Company's expectations concerning relationships with strategic partners, suppliers, regulatory bodies and other third parties; our ability to consummate the proposed business combination and PIPE and the satisfaction or waiver of the closing conditions set forth in the proposed business combination or PIPE subscription agreements; the occurrence of any other event, change or other circumstances that could give rise to the termination of the proposed business combination or PIPE subscription agreements; the expected timing of the closing of the proposed transaction; the expected listing of the combined company's securities on Nasdaq; and the potential benefits of the proposed transaction and expectations related to its terms and timing.

These forward-looking statements are provided for illustrative purposes only and are not intended to serve as, and must not be relied on as, a guarantee, an assurance, a prediction or a definitive statement of fact or probability. Actual events and circumstances are difficult or impossible to predict and will differ from assumptions, many of which are beyond the control of the Company and Churchill XI.

PORTLAND, Ore., Oct. 15, 2026 /PRNewswire/ -- Mueon Corporation, a semiconductor systems company building a new modular foundation for AI and hyperscale computing, today announced $65 million raised in a Series A. Maverick Silicon led the financing, with participation from Intel Capital, Geodesic Alliances Fund, Oregon Venture Fund, M-Ventures, Wellington Capital, IQT, and Defined.

The new capital marks Mueon's next phase of growth after emerging from stealth with a $15.5 million seed round in 2025, bringing capital raised to over $80M to date. The company is using the Series A funding to expand its engineering and operations teams, transition Cubelets™ from the platform development phase towards broader system validation and production readiness, and deepen its growing customer engagements.

"This financing gives us the scale to bring the next generation of compute and memory system-scale integration to market," said Wilfred Gomes, co-founder and CEO of Mueon Corporation. "Mueon's architecture is built to move past today's rack-level constraints and deliver the kind of density the rest of the industry is only beginning to chart a path toward."

Exponential™ Computing Platform Built for the System Scale Era

Mueon's core architectural concept is Cubelets™: modular, three-dimensional (3D) compute + memory building blocks. Rather than optimizing each subsystem independently, Mueon is developing the platform around the data movement, power density, and deployment constraints that increasingly define AI infrastructure economics. Cubelets™ densify compute at the system level, reducing the physical distance data has to travel and the power cost that comes with moving it, without requiring the sprawl of a traditional server rack. The architecture treats packaging, interconnect, power, and thermals as first-class design variables rather than separate problems to solve after the fact, extending beyond any single accelerator technology.

Since its seed financing, Mueon has broadened the program across four execution tracks:

- Silicon and system architecture: Advancing the compute, memory, and interconnect architecture required to turn Cubelets™ into scalable 3D systems.

- Advanced integration: Developing packaging, power-delivery, and thermal approaches needed for much higher compute density without simply reproducing rack-level complexity at a smaller scale.

- Software and system orchestration: Building the software layer needed to make modular hardware usable through familiar AI frameworks and deployment workflows.

- Ecosystem validation: Working with technology, manufacturing and industry partners to validate components, integration choices and the path from prototype to production.

"The Mueon team combines deep expertise in the technologies that define modern data centers with the experience to deploy those technologies at system scale," said Manish Muthal, Sr. Managing Director at Maverick Silicon.

As part of the financing, Manish Muthal will join Mueon's board of directors alongside Intel Capital Managing Director Srini Ananth.

"Mueon is continuing to reimagine data-center design at the fundamental level," said Srini Ananth, Managing Director at Intel Capital. "By bringing compute, memory, power delivery, and thermal management together into a single, integrated system, the team is building a path to scale AI infrastructure with better economics and efficiency, and this round reflects the engineering depth and ecosystem required to bring that vision to market."

Why the Architecture Matters Now

Mueon is targeting up to 10X gains in power and cost efficiency within the same rack footprint, with the architecture designed to scale toward megawatt-class density as demand grows.

"Mueon's Cubelets™ architecture creates new possibilities for partners such as d-Matrix," said Sudeep Bhoja, Co-founder and CTO of d-Matrix. "Combined with in-memory compute, a modular system architecture can enable smaller, denser infrastructure tailored for AI workloads and allow us to experiment, optimize, and deploy at new scales."

"Large-scale data centers have been constrained by power and cooling limits for years," said Rohit Vidwans, Co-CEO of Ampere Computing, now part of SoftBank. "Mueon's modular approach rethinks the physical building blocks of infrastructure. We are pleased to work with the Mueon team as it de-risks the technology on the path toward production."

About Mueon

Mueon Corporation is developing an Exponential™ Computing Platform for AI and hyperscale infrastructure. Its Cubelets™ architecture uses modular, stackable building blocks to tightly integrate compute, memory, interconnect, power delivery, and thermal management to increase deployable compute density while reducing system complexity, power, and infrastructure overhead.

Headquartered in Portland, Oregon, Mueon brings together engineers and industry leaders with experience across CPU and GPU architecture, memory systems, advanced packaging, high-speed I/O, power delivery, thermal engineering, and large-scale system design. For more information, visit mueon.com.

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RC Mowers to unveil next evolution in commercial mowing at Equip Expo

Robotic mowing manufacturer is launching a new autonomous mower and expanding its product line

GREEN BAY, Wis., Oct. 15, 2026 /PRNewswire/ -- RC Mowers, a leading manufacturer of robotic and autonomous mowers, announced today it will unveil a completely new autonomous commercial mower platform and an all-season accessory lineup that takes its remote-controlled slope mowers beyond mowing for the first time at Equip Expo Booth No. 7056, Oct. 20-23 in Louisville, Kentucky.

The company will give dealers and reporters the first look at its new mowing and grounds solutions during the Indoor Trade Show Dealer & Media Preview from 9 a.m. to noon Wednesday, Oct. 21. The solutions will then be unveiled to all Equip attendees beginning at noon. The new products will expand what RC Mowers equipment can accomplish in the field and introduce customers to both efficiency improvements and new lines of revenue for their businesses.

"We're bringing two major innovations to Equip: an all-new autonomous mower and new ways to put our slope machines to work beyond mowing," said RC Mowers CEO Michael Brandt. "Our customers need equipment that delivers value every day. That means helping them cover more ground with fewer people, maximize their investment and keep their machines working throughout more of the year."

More Capabilities, More Opportunities

RC Mowers' new solutions will take aim at some of the biggest challenges facing commercial landscapers and public works departments.

With labor shortages, rising operating costs and increasing demands on grounds maintenance crews, contractors and municipalities need equipment that helps them accomplish more with the resources they already have. RC Mowers' new products will demonstrate how the company is continuing to push the boundaries of what robotic and autonomous equipment can deliver.

The new autonomous mower platform will help commercial crews cover more ground by increasing productivity and freeing up employees to focus on higher-value tasks. The company also plans to expand the capabilities of its R-Series remote-controlled slope mowers, creating opportunities for contractors to offer additional services, generate new revenue and put their equipment to work throughout the year.

RC Mowers developed its new product line with those operating realities in mind, drawing on field research and firsthand insight into the challenges contractors and public works crews encounter every day.

"These products grew out of conversations with our customers," Brandt said. "We listened to what they said was slowing their crews down, where their equipment was falling short, and what would help them take on more work. We took those challenges back to our team and looked for practical ways to solve them. What we're bringing to Equip is a direct result of those conversations."

A Look Ahead

Equip Expo is one of North America's largest trade shows for outdoor power equipment, landscape and hardscape professionals. The 2026 event is expected to feature more than 1,100 exhibits, 30 acres of outdoor demonstrations and thousands of products for landscape contractors, dealers, and other industry professionals.

The event begins Oct. 20 with a welcome reception at Churchill Downs, followed by the trade show Oct. 21-23 at the Kentucky Exposition Center.

For more information about Equip, visit EquipExposition.com. For more information about RC Mowers, visit rcmowersusa.com.

About RC Mowers

RC Mowers designs and manufactures U.S.-made autonomous and remote-controlled robotic mowers that help businesses reduce labor demands, improve operator safety, and maintain large and hard-to-access green spaces more efficiently. Serving landscaping contractors, public works departments, municipal, state, and federal parks systems, and road departments, the company supports customers through a nationwide network of authorized dealers and service partners. Founded in 2018 and based near Green Bay, Wisconsin, RC Mowers is redefining the business of mowing. For more information, visit rcmowersusa.com.

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- New designation expands on first Fast Track Designation in TMB-H colorectal cancer and is supported by monotherapy responses across multiple tumor types in the STARt-001 study

- Invikafusp alfa believed to be first immuno-oncology T-cell agonist to receive Fast Track Designation in a biomarker-defined, tissue-agnostic indication

- New designation supported by updated Phase 2 data in this population, which will be featured in an oral presentation at the European Society for Medical Oncology (ESMO) Congress 2026 on October 23

CAMBRIDGE, Mass., Oct. 15, 2026 /PRNewswire/ -- Marengo Therapeutics Inc., a clinical-stage biotechnology company pioneering precision immunotherapies for oncology and inflammation and immunology (I&I), today announced that the U.S. Food and Drug Administration (FDA) has granted a second Fast Track Designation (FTD) to invikafusp alfa for the treatment of unresectable, locally advanced, or metastatic, tumor mutational burden high (TMB-H) solid tumors that have progressed following prior treatment including immune checkpoint inhibition and who have no satisfactory treatment options.

The new designation expands invikafusp alfa's Fast Track status from a single tumor type, TMB-H colorectal cancer (granted January 2025), to TMB-H solid tumors regardless of their tissue of origin. It is supported by objective responses across multiple tumor types, including colorectal, gastric, breast, urothelial, endometrial, gastroesophageal, head and neck, and lung cancers, in the ongoing Phase 1/2 STARt-001 study, with initial data presented at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting. Updated Phase 2 results will be presented in an oral session at ESMO 2026 in Madrid on October 23.

"Years ago, when we pursued the tumor-agnostic TMB-H approval for pembrolizumab, the premise was that a high mutational burden gives T cells more to recognize. Yet many patients with TMB-H tumors do not respond to PD-1 blockades, such as pembrolizumab, or progress after it and are left with few treatment options," said Eric Rubin, M.D., member of Marengo's Scientific Advisory Board and former Senior Vice President of Global Clinical Oncology at Merck, where he led the initial development of pembrolizumab. "Invikafusp alfa takes a fundamentally different approach: rather than releasing a checkpoint on exhausted T cells, it directly expands new T cells that can act on that antigen-rich landscape. That makes it a compelling candidate for patients whose tumors do not or no longer respond to PD-1-directed therapy, regardless of where the tumor arises."

"A second Fast Track Designation, now in a pan-tumor setting, reinforces our conviction that invikafusp alfa can become a next-generation, tissue-agnostic immuno-oncology backbone," said Ke Liu, M.D., Ph.D., Chief Development Officer of Marengo Therapeutics. "Across multiple clinical data sets, invikafusp alfa has shown encouraging monotherapy activity in heavily pretreated patients across tumor types that were either insensitive to checkpoint inhibitors or progressed after PD-1–directed therapy. In parallel, we are evaluating invikafusp alfa in combination with standard-of-care therapies, including an antibody-drug conjugate, to support its potential in earlier lines of therapy. We look forward to presenting Phase 2 STARt-001 data at ESMO later this month."

Invikafusp alfa received its first FDA Fast Track Designation for the treatment of unresectable, locally advanced or metastatic colorectal cancers with TMB-H in January 2025.

Invikafusp alfa is investigational and has not been approved by the FDA or any other regulatory authority.

About Fast Track Designation

Fast Track Designation is an FDA process designed to facilitate the development and expedite the review of drugs that treat serious conditions and fill an unmet medical need. It provides more frequent communication with the FDA and, for drugs that meet the relevant criteria, eligibility for rolling review, Accelerated Approval, and Priority Review.1

About TMB-High Solid Tumors

Tumor mutational burden measures the number of somatic mutations in a tumor's genome. Tumors with high TMB (≥10 mutations/megabase) occur across many cancer types. Patients whose TMB-H tumors progress on or after checkpoint inhibitor therapy, or who are not candidates for it, have limited treatment options.

About Invikafusp alfa (STAR0602)

Invikafusp alfa (STAR0602), the lead candidate from Marengo's STAR™ platform, is a first-in-class, bispecific dual T-cell agonist. It is designed to selectively activate a common Vβ T-cell subset found in all cancers by combining a non-clonal mode of TCR activation with a T-cell co-stimulatory signal in a single molecule. This approach promotes the expansion of clonally diverse, effector memory Vβ T cells, enhancing antitumor immunity and enabling durable tumor clearance. Invikafusp alfa was designed to restore and amplify antitumor immunity in patients who have progressed on, or are insensitive to, prior immune checkpoint blockade.

About the STARt-001 Clinical Study

STARt-001 is a global Phase 1/2 trial evaluating invikafusp alfa monotherapy in patients with advanced, antigen-rich solid tumors that are refractory or resistant to PD-1–directed therapy. The Phase 2 portion uses biomarker-enriched cohorts, including TMB-H and MSI-H, to assess activity across multiple tumor types and help identify patients most likely to benefit. For more information, visit ClinicalTrials.gov (NCT05592626). Phase 2 expansion is ongoing to further investigate invikafusp for the treatment of ICB-resistant tumors.

About Marengo Therapeutics

Marengo Therapeutics, Inc., a clinical-stage biotech company, develops novel TCR-targeting antibodies that selectively modulate common and disease-specific T cell subsets of the germline TCR repertoire to provide lifelong protection against cancer and autoimmune diseases. With a passionate team of dedicated scientists experienced in immunology and oncology, and three proprietary platforms: Selective T Cell Activation Repertoire (STAR), Trispecific T Cell Engager (Tri-STAR) and T cell Depletor (MSTAR), Marengo is working to selectively target the right T cells in the right patients to create a world in which everyone's immune system can defeat cancer and autoimmune diseases. To learn more, visit marengotx.com.

Contacts:

Media | Peg Rusconi I [email protected]

Investors | Anne Marie Fields | [email protected] 

1 Fast Track | FDA (2025, September 28)

SOURCE Marengo Therapeutics

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FRIENDSWOOD, Texas, Oct. 15, 2026 /PRNewswire/ -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that it will release its financial results for the third quarter and nine months ended Sept. 30, 2026, after the close of market on Thursday, Nov. 5, 2026.

Company management will host a webcast to discuss its financial results at 4:30 p.m. Eastern time on the same day.

Webcast Details

The live webcast can be accessed here: https://event.choruscall.com/mediaframe/webcast.html?webcastid=tHS7IFft, or via the webcast link on the Investor Relations page of the Company's website: https://ir.castlebiosciences.com/. Please access the webcast at least 10 minutes before the start time. A replay of the webcast will be available following its conclusion.

There will be a brief Question and Answer session following management commentary.

About Castle Biosciences

Castle Biosciences (Nasdaq: CSTL) is a leading diagnostics company improving health through innovative tests that guide patient care. With a primary focus in dermatologic and gastroenterological disease, we develop personalized, clinically actionable solutions that help improve disease management and patient outcomes.

We put people first—empowering patients and clinicians and informing care decisions through rigorous science and advanced molecular tests that support more confident treatment planning. To learn more, visit www.CastleBiosciences.com and connect with us on LinkedIn, Instagram, Facebook and X.

DecisionDx-Melanoma, DecisionDx-CMSeq, i31-SLNB, i31-ROR, DecisionDx-SCC, MyPath Melanoma, AdvanceAD-Tx, TissueCypher, Esopredict, DecisionDx-UM, DecisionDx-PRAME and DecisionDx-UMSeq are trademarks of Castle Biosciences, Inc.

Investor Contact:

Camilla Zuckero

[email protected] 

Media Contact:

Allison Marshall

[email protected] 

SOURCE Castle Biosciences, Inc.

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The Project Was Funded by a $9.68 Million New York Statewide Health Care Facility Transformation Program Fund

BRONX, N.Y., Oct. 15, 2026 /PRNewswire/ -- Elected officials and Montefiore Einstein staff proudly unveiled a newly renovated labor and delivery (L&D) suite at Jack D. Weiler Hospital. Funded by a $9.68 million New York Statewide Health Care Facility Transformation Program grant, the Weiler Mother Baby Unit located on the sixth floor at 1825 Eastchester Road includes a redesigned workflow and capital upgrades to its L&D rooms, maternal surgical suite, and triage and waiting areas.

"Our hospital is the only regional perinatal center in the Bronx, taking care of the highest risk pregnancies across the Bronx and part of Queens," said Angela Gonzalez-Perez, MPA, FACHE, Vice President of Operations and Executive Director, Jack D. Weiler Hospital. "It was of the utmost importance for us to ensure that our patients experience a warm, welcoming environment where they can receive the finest care possible. Thanks to the tremendous support from New York State, this newly renovated space serves as the physical embodiment of our vision of being a premier academic medical center that transforms health and enriches lives."

Enhancing Experiences for Bronx Patients

The modernized Unit includes state-of-the-art upgrades to L&D rooms with ensuite bathrooms; a reconfigured clinician team station and workflow; a modernized triage area with six triage bays and one evaluation triage bay; a modernized maternal surgical suite with a dedicated C-Section Post-Anesthesia Care Unit including four bays; and upgrades to the three Delivery Room Operating Rooms. Additionally, lighting has been enhanced throughout the Unit offering a more comfortable and soothing environment. Montefiore Einstein has also invested in remote monitoring tools to support the patients and clinical teams and is offering new food options to enhance the patient experience.

Under the leadership of Mark H. Einstein, M.D., M.S., who became the Chella and Moise Safra Endowed Chair, Department Chair of Obstetrics & Gynecology and Women's Health in 2024, 26 new physicians specializing in areas including critical care obstetrics, adolescent medicine and onco-fertility, in addition to nurse practitioners and physician assistants have been on-boarded to support care. Services like universal depression screening in the hospital, collaborative care with reproductive psychiatry, a specialized postpartum outpatient clinic for individuals with medically complex or high-risk pregnancies, as well as a cardiac maternal medicine program also continue to grow. Dr. Einstein's leadership team has been instrumental in the design of the newly unveiled Unit.

"With the new technology upgrades and redesigned workflows, we are equipped to take care of the most complex cases and do so in a beautiful new family friendly atmosphere," said Rodney Wright, M.D., Vice Chair, Obstetrics.

"I couldn't be prouder to unveil this unit and continue growing our department and offerings to support our patients and their loved ones," said Mark H. Einstein, M.D., M.S., who is also a professor of Obstetrics & Gynecology and Women's Health (Gynecological Oncology) at Albert Einstein College of Medicine.

The renovation of the L&D has been conducted in phases with no interruption to patient care. Five of the six phases are complete, with the final phase including renovations of the last two L&D rooms, plus a back service elevator upgrade, planned for completion in early 2027.

SOURCE Montefiore Health System

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20 Lenovo and HKC Monitors Among First to Receive TÜV Rheinland Native Gaming Performance Certification

Framework combines native performance with human-factor evaluation to connect measurable specifications with real gaming experiences.

SHANGHAI, Oct. 15, 2026 /PRNewswire/ -- Following the official launch of the TÜV Rheinland Native Gaming Performance Standard at the 23rd China Digital Entertainment Expo & Conference (ChinaJoy) in July 2026, the certification framework is now being adopted across the gaming display industry. Recently, multiple gaming monitors from Lenovo's Legion series and ANTGAMER earned TÜV Rheinland Native Gaming Performance Certification, making them among the first products certified under the new standard. ANTGAMER is an esports brand under HKC which was established in Shenzhen in 2001.

Higher refresh rates and shorter advertised response times do not necessarily translate into clearer, more stable gaming visuals. When such specifications depend on overclocking, undisclosed reductions in display quality or compromises in stability, the actual experience may fall short of product claims. TÜV Rheinland's framework addresses this challenge by evaluating both the accuracy of performance claims and the quality of the gaming experience.

The Native Gaming Performance evaluation system was developed to provide consumers with a transparent and measurable benchmark for assessing gaming displays. The standard clearly defines three refresh-rate operating modes, namely native, overclocked, and dual-mode, while establishing a "same mode, full-system testing" principle. Refresh-rate overclocking is excluded from certification, ensuring performance claims are assessed under consistent and realistic operating conditions.

Designed around the core requirements of gamers, the certification framework evaluates products across three key dimensions: motion performance, image quality, and visual comfort. Fourteen indicators are assessed under these dimensions. Different weighting factors are applied according to competitive, immersive, and all-around gaming scenarios; the weighted results are then summed to produce the final Gaming Performance Index (GPI), which is converted into a three- to five-star rating. The methodology also incorporates human-factor studies, including dynamic visual acuity assessments, eye-tracking analysis, and first-person shooter gaming tests. These convert subjective gaming experiences into quantifiable data and deliver a more comprehensive measurement of perceived motion clarity.

Advancing the Gaming Display Industry Toward Real-World Performance

Jay Yang, Global Senior Vice President of Electrical at TÜV Rheinland, stated: "The Native Gaming Performance Standard was introduced to help consumers identify products that genuinely deliver high-level gaming experiences. The successful certification of multiple Lenovo Legion and ANTGAMER monitors demonstrates both manufacturers' continued commitment to display innovation and the practical applicability of the standard across the industry."

He added that the certification framework combines a unified definition of native performance, full-system testing methodologies, human-factor validation, and scenario-based star ratings. This encourages the gaming display industry to move beyond specification-driven competition toward performance evaluated through real-world testing. The program also supports consumers in making informed purchasing decisions while ensuring certification integrity through ongoing standards updates and production-sample surveillance.

Sixteen Lenovo Legion Monitors Receive 3-Star to 5-Star Ratings

As Lenovo's flagship gaming monitor lineup, the Legion series is designed to deliver high refresh rates, low latency, and premium image quality. In this certification project, 16 Legion monitors received TÜV Rheinland Native Gaming Performance ratings ranging from three to five stars, reflecting Lenovo's comprehensive product portfolio from entry-level to flagship offerings.

5-Star Certified Models (4): Legion 27Q-10 OLED, Legion Pro 27Q-10, Legion Pro 27UD-10, Legion Pro 32UD-10

4-Star Certified Models (7): Legion 34W-2c, Legion 32Q-2C, Legion 27U-10, Legion 27U-20, Legion 27QD-10, Legion 27Q-20, Legion 27Q-2c

3-Star Certified Models (5): Legion 27Q-10, Legion 27-2c, Legion 27-1r, Legion 25-10, Legion 24-1r

George Toh, Vice President and General Manager, Visuals Business, Lenovo's Intelligent Devices Group, said: "The TÜV Rheinland Native Gaming Performance Certification awarded to 16 Legion monitors is strong recognition of our continued investment in gaming display technologies and our commitment to prioritizing real-world user experiences. Certification across the full range of ratings, from three to five stars, demonstrates the ability of our product portfolio to meet the diverse needs of gamers at every level. We look forward to further strengthening our collaboration with TÜV Rheinland to deliver clearer, smoother, and more comfortable visual experiences for gamers worldwide."

Four ANTGAMER Monitors Earn 5-Star Certification

Following comprehensive testing and evaluation by TÜV Rheinland, four gaming monitors from HKC's ANTGAMER brand, namely ANT25ASF, ANT255TQ, ANT275TQ, and ANT272TUE, met the requirements of the Native Gaming Performance Standard and received the highest 5-Star Certification.

Covering FHD, QHD, and UHD resolutions, the certified models are designed to address the performance requirements of professional esports players, dedicated gaming enthusiasts, and premium entertainment users seeking high-performance gaming displays.

Peng Xinchun, General Manager of Brand Operations at ANTGAMER, commented: "Receiving TÜV Rheinland's 5-Star Native Gaming Performance Certification validates our ability to deliver clear, smooth, and precise visual experiences in real gaming scenarios. Going forward, HKC will continue working closely with TÜV Rheinland to provide consumers with superior display technologies and enhanced visual experiences."

About TÜV Rheinland

TÜV Rheinland is a leading provider of testing, inspection and certification services worldwide. For over 150 years, the company has helped make the world a safer place. Today, more than 29,000 employees test, inspect and certify products, plants and processes, while also providing training for people in a wide range of professions. Operating from 500 locations in more than 50 countries, TÜV Rheinland helps safeguard key areas of business and everyday life. Headquartered in Cologne and generating annual revenue of close to €3 billion, the company plays a key role in quality assurance worldwide. TÜV Rheinland has been a member of the UN Global Compact since 2006, demonstrating its commitment to anti-corruption and sustainability.

SOURCE TÜV Rheinland

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Crest Coating Earns AS9100D Certification, Expanding Its Role as a Coating Source for Aerospace and Defense

Anaheim industrial finisher, founded in 1967, adds the aerospace industry's quality management standard.

ANAHEIM, Calif., Oct. 15, 2026 /PRNewswire/ -- Crest Coating, Inc., a Southern California specialist in industrial powder coating and functional liquid coatings, today announced that it has earned AS9100D certification from Amtivo. The certification covers the application of powder, Teflon, Xylan®, Halar®, and BCS bakeware coatings.

AS9100 is the quality management standard developed by the International Aerospace Quality Group for companies that supply the aviation, space and defense industries. It builds on ISO 9001 with added requirements for product safety, traceability, risk management, counterfeit-part prevention and on-time delivery. Aerospace manufacturers and their suppliers commonly require it before approving a source for flight hardware and defense programs.

"Our team spent eight months building a quality system that meets the standard aerospace customers hold every critical supplier to," said Jeff Erickson, CEO of Crest Coating. "For our customers, it means the coating work we do under this certification is backed by documented traceability, disciplined inspection and processes designed to catch problems before they ever reach them. I'm proud of what our people accomplished, and we're ready to support more aerospace and defense programs."

From more than 50,000 square feet of production space in Anaheim, Crest serves customers in aerospace, defense, medical, semiconductor, electronics and industrial markets. Its capabilities also include dry-film lubricant, high-temperature and conformal coatings. In addition to AS9100D, Crest is ISO 9001:2015 certified, a Chemours Licensed Industrial Applicator, an approved applicator for Whitford Xylan®, and a Tiger Drylac 5-Star CARC applicator.

Aerospace and defense buyers can request Crest's AS9100D certificate and capability statement here or by calling 714-635-7090.

About Crest Coating

Founded in 1967, Crest Coating, Inc. specializes in industrial powder coating and functional liquid coatings from its Anaheim, California facility. The company serves customers in aerospace, defense, medical, semiconductor, electronics, automotive and commercial markets. Learn more at https://www.crestcoating.com/.

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CAPTION: Crest Coating employees gather at the company's Anaheim, Calif., facility to celebrate earning AS9100D certification.

This release was issued through Send2Press® on behalf of the news source. For more information, visit Send2Press Newswire at https://www.send2press.com/.

SOURCE Crest Coating, Inc.

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