LOS ANGELES, Sept. 8, 2026 /PRNewswire/ -- The Law Offices of Frank R. Cruz announces that investors with losses related to Hyliion Holdings Corp. (HYLN) have opportunity to lead the securities fraud class action lawsuit.

IF YOU ARE AN INVESTOR WHO SUFFERED A LOSS IN HYLIION HOLDINGS CORP. (HYLN), CLICK HERE BEFORE OCTOBER 27, 2026 (THE LEAD PLAINTIFF DEADLINE) TO PARTICIPATE IN THE ONGOING SECURITIES FRAUD LAWSUIT.

What Is The Lawsuit About?

The complaint filed in this class action alleges that between May 12, 2026 and June 23, 2026, Defendants made materially false and/or misleading statements, as well as failed to disclose material adverse facts about the Company's business, operations, and prospects. Specifically, Defendants failed to disclose to investors that: (1) in order to cause rapid price appreciation in Hyliion stock, Defendants announced a deal with an entity that was very recently formed and does not appear to have any actual business operations; (2) the Individual Defendants timed the announcement and foregoing price appreciation to insider trade; and (3) as a result, Defendants' statements about Hyliion's business, operations, and prospects, were materially false and misleading and/or lacked a reasonable basis at all relevant times.

Contact Us To Participate or Learn More:

If you wish to learn more about this action, or if you have any questions concerning this announcement or your rights or interests with respect to these matters, please contact us.

The Law Offices of Frank R. Cruz, 

Email us at: [email protected]

Visit our website at: www.frankcruzlaw.com

Follow us for updates on Twitter: twitter.com/FRC_LAW.

If you inquire by email, please include your mailing address, telephone number, and number of shares purchased.

To be a member of the class action you need not take any action at this time; you may retain counsel of your choice or take no action and remain an absent member of the class action.

This press release may be considered Attorney Advertising in some jurisdictions under the applicable law and ethical rules.

SOURCE The Law Offices of Frank R. Cruz, Los Angeles

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A+FCU Recognized as Best Consumer Digital Bank and Best Mobile Banking App in the United States

AUSTIN, Texas, Sept. 8, 2026 /PRNewswire/ -- A+ Federal Credit Union (A+FCU) is proud to announce it has been recognized by Global Finance, in partnership with Infosys, in the 2026 World's Best Consumer Digital Banking Awards, earning two prestigious honors in the United States region:

- Best Consumer Digital Bank

- Best Mobile Banking App

The recognition marks the second consecutive year A+FCU received the Best Mobile Banking App award and its first year earning the Best Consumer Digital Bank distinction, reinforcing the credit union's commitment to delivering an exceptional digital banking experience for its members.

"We're honored to receive these awards and especially proud to be recognized for a second year in a row as the #1 Mobile Banking App in the U.S.," said Brandon McGee, Chief Digital Strategy Officer of A+FCU. "Adding the 2026 Best Consumer Digital Bank award further validates the investments our A+ team has made to create a seamless, secure, and innovative digital experience that helps our members manage their finances anytime, anywhere."

Best Consumer Digital Bank Award winners were selected based on criteria including strength of strategy for attracting and servicing digital customers, growth of digital customers, breadth of product offerings, and evidence of tangible benefits gained from digital initiatives.

The award-winning A+ Mobile App continues to provide members with convenient, secure access to their accounts and financial tools, including:

- Biometric login and enhanced security features

- Real-time transaction alerts

- Card controls and budgeting tools

- Online account opening

- Mobile check deposit

- Instant money transfers between friends and family

- Free monthly credit score updates

- Streamlined direct deposit setup

- Live chat support

"As member expectations continue to evolve, we're focused on building digital solutions that make banking easier and more accessible," McGee said. "These awards reflect our team's dedication to innovation and our commitment to helping members live their A+ lives."

A+FCU members can download the A+ Mobile App from the App Store or Google Play to experience award-winning digital banking firsthand.

A+ Federal Credit Union was founded in 1949 by 50 Austin, Texas teachers. Over seventy-seven years later, A+FCU is an award-winning institution with more than 191,000 members throughout the community, $2.52 billion in assets, over 520 employees, and 22 branches. A+FCU supports members with a full range of financial products including home, auto, and business loans, checking and savings accounts, as well as digital banking solutions for banking on the go. Learn more at aplusfcu.org.

SOURCE A+ Federal Credit Union

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University of Benghazi Reopens After 11 Years in Historic Milestone, Breaking Three Guinness World Records

Engineer Belqasim Khalifa Haftar's Dream Project Brings One of Libya's Most Prestigious Educational Institutions Back to Life

BENGHAZI, Libya, Sept. 8, 2026 /PRNewswire/ -- On September 4, 2026, the University of Benghazi officially reopened all its faculties and facilities following a comprehensive reconstruction and rehabilitation project implemented by the Libyan Development and Reconstruction Fund, headed by its Director General, Engineer Belqasim Khalifa Haftar.

The reopening marked a historic milestone for higher education in Libya, restoring life to the university's main campus after more than eleven years of closure due to the extensive destruction it sustained during the Libyan Armed Forces' war against terrorist groups.

Engineer Belqasim personally followed the project's finest details. What began as a personal dream evolved into one of the Fund's most prominent educational initiatives. In an exceptional achievement, an integrated university city was rebuilt in just three years, providing a modern academic environment designed to serve current and future generations.

Known as the "Mother of Libyan Universities," the University of Benghazi is among the country's oldest and largest academic institutions, with nearly 100,000 students. Over the decades, it has provided free education and graduated generations of scientists, academics, experts and officials who have contributed to building Libya's institutions.

The project covered the Faculties of Engineering, Arts, Law, Science and Languages, alongside the central library, academic and administrative buildings, laboratories, service facilities, student residences, infrastructure and internal roads.

The inauguration ceremony welcomed prominent Libyan figures, ambassadors, international delegations and approximately 240 foreign guests. Led by Field Marshal Khalifa Haftar and Engineer Belqasim Khalifa Haftar, the event featured 3D mapping, advanced visual effects and an aerial drone performance that achieved three Guinness World Records: an eagle formation, a quill writing "University of Benghazi" across the sky and the formation of a peace symbol.

The Fund has also sent more than 1,000 university students abroad to continue their studies, combining physical reconstruction with investment in human capital.

The achievement forms part of more than 2,300 development projects being implemented across eastern and southern Libya. These include the rehabilitation of universities and educational institutions in Kufra, Al Bayda, Derna, Al Marj, Ajdabiya, Sirte, Brak al-Shati and Murzuq, alongside approximately 250 schools.

The reopening is therefore far more than the return of an educational institution: it restores one of Libya's most prominent scientific and historic landmarks to the heart of national life.

Photo - https://mma.prnewswire.com/media/3008957/Benghazi.jpg

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ILONA ANTONYAN NAMED TO THE NATION'S TOP ONE PERCENT BY THE NATIONAL ASSOCIATION OF DISTINGUISHED COUNSEL

Antonyan Miranda Founding Partner recognized among the nation's most distinguished family law attorneys

SAN DIEGO, Sept. 8, 2026 /PRNewswire/ -- Antonyan Miranda, LLP announced today that Founding Partner Ilona Antonyan has been selected as a member of the Nation's Top One Percent by the National Association of Distinguished Counsel (NADC), a distinction reserved for fewer than one percent of practicing attorneys nationwide.

Founded in 2014, NADC recognizes attorneys who elevate the standards of the legal profession and provide a benchmark for other lawyers to emulate. Candidates undergo a rigorous, three-tier vetting process: an initial review by NADC's research team, evaluation by a blue-ribbon panel of attorneys holding podium status with independently neutral legal organizations, and final approval by a judicial review board.

A Rigorous, Peer-Driven Standard of Excellence

As a Founding Partner of Antonyan Miranda and a Certified Family Law Specialist, Antonyan has built a reputation for guiding clients through complex, high-conflict, and high-asset divorce matters throughout San Diego, Orange, and Riverside Counties. Her selection to NADC's Nation's Top One Percent reflects a career defined by trial experience, sound judgment, and an unwavering commitment to the families she represents.

Ilona Antonyan, Founding Partner and Certified Family Law Specialist, stated: "Being named to the Nation's Top One Percent by NADC is a meaningful honor, especially given the rigor of the vetting process behind it. Family law is deeply personal work, and this recognition belongs as much to my clients and my team at Antonyan Miranda as it does to me. I'm grateful for the trust our clients place in us every day."

Antonyan joins a select group of attorneys nationwide recognized by NADC for demonstrating the highest ideals of the legal profession, further strengthening Antonyan Miranda's standing as one of Southern California's premier family law firms.

About Antonyan Miranda

Founded in 2015 by Ilona Antonyan and Timothy Miranda, Antonyan Miranda is a San Diego-based family law firm recognized for its depth of Certified Family Law Specialists and successful track record in complex, high-conflict, and high-asset divorce matters. The firm holds one of the highest concentrations of State Bar of California Certified Family Law Specialist designations in Southern California. With offices serving San Diego County, Orange County, and Riverside County, the firm handles high-asset divorce, contested child custody, business valuation in divorce, executive compensation disputes, and complex property division.

Media Contact:

Patrick Froehlke

619-696-1100

[email protected]

www.antonyanmiranda.com 

SOURCE Antonyan Miranda, LLP

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Green Dispensary Expands to Northwest Las Vegas with Opening of Fourth Nevada Location

New Decatur and Ann location brings Green's neighborhood dispensary experience, curated Nevada cannabis selection, and convenient shopping options to northwest Las Vegas

LAS VEGAS, Sept. 8, 2026 /PRNewswire/ -- Green Dispensary officially announced that Green Dispensary North, its fourth Nevada location, is now open at 5530 N Decatur Blvd, Suite 115, Las Vegas, NV 89130.

Located near Decatur Boulevard and Ann Road, the new dispensary serves customers across northwest Las Vegas, North Las Vegas, Centennial Hills, and Aliante. Green Dispensary North is open daily from 8:00 a.m. to midnight and offers in-store shopping, order-ahead pickup, curbside pickup, drive-thru service, and delivery.

"Green has always been about making the dispensary experience feel local, straightforward, and genuinely helpful," Green Dispensary said in a statement. "Opening on Decatur allows us to serve more of the north and northwest valley with the knowledgeable service, fair pricing, and carefully selected products our customers have come to expect from Green."

Green Dispensary North carries a broad selection of flower, pre-rolls, vapes, edibles, concentrates, tinctures, topicals, cannabidiol products, and accessories. Customers can shop with assistance from Green's budtenders or browse the location's live online menu before visiting.

The new location was designed to make shopping simple regardless of how customers prefer to order. Walk-in customers can explore the full menu with guidance from the store team, while customers short on time can place orders online for pickup, curbside service, or drive-thru collection. Delivery is also available to eligible addresses within the store's service area.

Green Dispensary North also participates in the Green Rewards program, allowing members to earn points on eligible purchases and access member offers across Green locations.

The opening expands Green's neighborhood footprint to four Nevada dispensaries, joining its existing locations in Rainbow, Hualapai, and Henderson. Each store combines a curated cannabis menu with approachable service and convenient online ordering.

About Green Dispensary

Green Cannabis Co. is a locally owned, state-licensed Nevada dispensary serving customers through four locations in Las Vegas. Green offers a curated selection of cannabis products at competitive prices, supported by knowledgeable budtenders who help customers explore options based on their individual preferences. Customers can browse live menus and place orders online for pickup or other available fulfillment options at https://greennv.com.

Cannabis products are intended only for consumers legally eligible under Nevada law. Please consume responsibly and keep cannabis products out of reach of children.

Media Contact

Andrew Kellogg

Del Mar Advertising

[email protected]

623-606-8891

SOURCE Green Dispensary

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VERO BEACH, Fla., Sept. 8, 2026 /PRNewswire/ -- Watercrest Senior Living is proud to donate a community bus from Watercrest St. Lucie West Assisted Living and Memory Care to support local children during police raids, rescues and other crisis situations. The senior living bus will be transformed into a warm, welcoming and comforting space where children feel safe and cared for in challenging situations.

Bobi Kruemberg, Executive Director of Watercrest St. Lucie West, also serves as a board member for United Against Child Trafficking (UACT). During a recent meeting, Kruemberg learned of the critical need in the Port St. Lucie area for a mobile medical rescue unit to serve children in crisis situations. As Watercrest St. Lucie West had recently acquired another transport bus, Kruemberg spearheaded the donation of the bus with the Watercrest organization in full support.

"This project reflects a commitment to Watercrest's principles in serving a purpose greater than ourselves," says Marc Vorkapich, Principal and CEO of Watercrest Senior Living Group. "We are honored that a bus once used to serve our residents can now be repurposed to serve the critical needs of children in our community."

The bus renovation will require approximately $50,000 in materials and services, and the St. Lucie community has responded with an outpouring of generosity. A local craftsman recently volunteered to complete the exterior work, representing an estimated $15,000 donation to the project. Once renovated, the bus will feature a warm, inviting interior with cozy furnishings, soft blankets, and toys to provide a sense of security and reassurance when children are removed from challenging or unsafe circumstances.

"Our Watercrest residents and associates immediately understood the significance of this project," says Bobi Kruemberg, Executive Director of Watercrest St. Lucie West. "They are making blankets and donating toys for the bus so that every child can receive a gift blessed with love, prayers and the message that they are valued, protected and cared for."

Watercrest St. Lucie West is a signature Watercrest product providing 102 assisted living and 26 memory care apartments with resort-style service and breathtaking lakeside views. The community boasts an exquisite design with stunning promenade, fireplace, signature water wall, multiple dining options, pool, salon and spa, grand balconies and Florida style outdoor living spaces with picturesque water views. Watercrest St. Lucie West is conveniently located at 279 NW California Boulevard along Florida's breathtaking Treasure Coast, just minutes from abundant dining, entertainment, and retail options. For information, contact the community at 772-758-7472.

About Watercrest Senior Living Group

Watercrest Senior Living Group was founded to honor our mothers and fathers, aspiring to become a beacon for quality in senior living by surpassing standards of care, service and associate training. Watercrest senior living communities are recognized for their luxury aesthetic, exceptional amenities, world-class care, and innovative memory care programming offering unparalleled service to seniors living with Alzheimer's and dementia. A nine-time certified Great Place to Work, Watercrest specializes in the development and operations of assisted living and memory care communities and the growth of servant leaders. For information, visit www.watercrestseniorliving.com.

SOURCE Watercrest Senior Living Group

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Historic Midtown Manhattan Hotel Introduces Thoughtfully Redesigned Guestrooms and Corridors Anchored by Exclusive Artwork Curated in Partnership with The Al Hirschfeld Foundation

NEW YORK, Sept. 8, 2026 /PRNewswire/ -- The Algonquin Hotel, Autograph Collection, one of New York City's most storied literary landmarks, announces the completion of a full renovation of all guestrooms, elevators, and corridors, unveiling a reimagined residential experience that pays tribute to the hotel's legacy while opening a new chapter for this haven of creativity. Completed through a carefully phased, multi-year renovation process, the project was quietly executed while the hotel remained fully operational, preserving the guest experience throughout construction.

Led by Brooklyn-based interior design firm CRÈME / Jun Aizaki Architecture & Design in collaboration with LUCID, the design and development arm of leading hospitality management company Highgate Hotels, the redesign was guided by two central ideas: honoring The Algonquin's legacy and creating an ode to New York City. Drawing inspiration from the hotel's history as a gathering place for writers, performers, and academics, the refreshed guestrooms and corridors echo the hotel's long-standing irreverence and intimacy while channeling the layered creative energy of today's Manhattan.

"The Algonquin Hotel has long served as a safe haven for wild minds, a quiet place along Club Row in the center of the wonderful whirlwind that is New York City ", said Willis Loughhead, General Manager of The Algonquin, in his 6th year at the helm. "Our focus was to honor the past without being beholden to it; timeless rooms were built where creativity can be sparked, and our landmark charm will be enlivened."

Without altering the hotel's historic footprint, CRÈME leaned into the intimacy and scale of the guestrooms, embracing their proportions and allowing the original framework of the building to shape the experience. The result is a collection of layered, residential spaces designed to feel sophisticated and personal.

Each guestroom and suite is anchored by a custom triptych artwork featuring exclusive Al Hirschfeld pieces, curated in partnership with The Al Hirschfeld Foundation and Director David Leopold, including a gold leaf-accented Central Park illustration that is exclusive to The Algonquin Hotel. Throughout the corridors, visitors will discover archival Hirschfeld works spanning theater, music, literature and popular culture, with each floor featuring its own unique collection. The works selected were drawn from the entirety of Al Hirschfeld's 80-year career in New York City, with many of the pieces not publicly displayed in decades and others sourced exclusively from the Foundation's archives specifically for the hotel. Rather than presenting the artwork in a traditional gallery, the pieces are intentionally woven throughout the property to create a one-of-a-kind collection that encourages curiosity and conversation.

"The Algonquin and Al Hirschfeld share a uniquely New York story rooted in creativity, character and storytelling," said David Leopold of The Al Hirschfeld Foundation. "Together, the hotel and foundation curated a collection that can't be found anywhere else and an immersive experience where every hallway, room and detail invites guests to engage with art and storytelling in a deeply personal way."

The renovation also introduces unexpected design details such as oversized luggage-tag-inspired room signage featuring 181 individually curated quotes from legends who created or influenced the hotel. Each guestroom displays its own distinct message from a diverse cast of characters and past residents such as Kermit the Frog, Maya Angelou, John Leguizamo, The Notorious B.I.G., Dorothy Parker, and The Vicious Circle; all cultural figures with ties to The Algonquin Hotel Times Square and the city of New York City. Subtle Art Deco references and jazz-inspired patterns appear throughout the design, including rhythmic corridor carpeting that reflects the movement and improvisation of music while nodding to the era of the famed Algonquin Round Table.

Additional design details include brass fixtures, layered lighting, custom marble-topped furnishings inspired by the hotel's original stairwells and integrated architectural elements that enhance warmth and functionality throughout the historic building. Rich walnut woods, ebonized oak, aged bronze finishes, and plush charcoal velvet headboards create warmth within the rooms, while a palette of deep and light celadon, peacock green, charcoal, and soft neutrals evoke the charisma and comfort of past and present Manhattan.

The hotel's culinary experience has also evolved alongside the renovation, with new menu items and cocktails served alongside redesigned menus at The Blue Bar Restaurant & Lounge, also created in collaboration with The Al Hirschfeld Foundation. Featuring archival Hirschfeld drawings, the refreshed offerings extend the hotel's design narrative while honoring the artists, performers and personalities that have long shaped The Algonquin's cultural identity.

Since opening in 1902, The Algonquin Hotel has occupied a singular place within New York's cultural fabric, serving as both a refuge and meeting place for generations of literary, theatrical and creative figures. With the completion of its guestroom renovation, the hotel continues that legacy while creating space for a new generation of stories, conversations and discoveries to unfold. For more information on The Algonquin Hotel, visit www.algonquinhotel.com.

Images of Renovated Guest Rooms at The Algonquin Hotel HERE (Photo Credit: Michael Kleinberg, The Algonquin Hotel).

About The Algonquin Hotel, Autograph Collection:

Since opening its doors in 1902, The Algonquin Hotel has stood as a cultural landmark and one of New York City's most storied hotels. Just steps from Times Square and Fifth Avenue, the hotel has long been a gathering place for the city's literary and cultural elite. Most famously, the Algonquin Round Table of the 1920s brought together luminaries such as Dorothy Parker, Robert Benchley, Harold Ross, Alexander Woollcott, Franklin Adams, and Robert Sherwood — a circle of wit and intellect that helped shape American literature and journalism. It was within these walls that The New Yorker magazine was conceived, further cementing the hotel's place in cultural history. Today, the 181-room hotel continues to honor its timeless legacy while welcoming modern travelers to create stories of their own. Guests can enjoy refined dining at the Round Table Restaurant, handcrafted cocktails at the Blue Bar, and the hotel's distinctive blend of history, charm, and style. The Algonquin was recently inducted into Historic Hotels of America®, the official program of the National Trust for Historic Preservation recognizing the nation's most iconic historic hotels and named one of the Top 25 New York City Hotels by readers of Conde Nast Traveler. For more information, please visit www.algonquinhotel.com.

SOURCE The Algonquin Hotel, Autograph Collection

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Featuring Haley Van Voorhis, who made NCAA College Football History three years ago, the campaign drives home a simple truth; a healthy body and a healthy planet share the same foundation of preparation, restoration, and resilience.

THE PLAINS, Va., Sept. 8, 2026 /PRNewswire/ -- ACRE Investment Management, a leading natural capital investment platform, today launched Playbook for the Planet, a new campaign built around a simple idea: healthy people depend on a healthy environment.

At the center of the campaign is Haley Van Voorhis (instagram.com/haleyvanv), who made NCAA college football history in September 2023. Her journey in football reflects the preparation, persistence, and resilience required to challenge expectations and create lasting change.

Those same qualities have shaped ACRE's approach to restoring natural systems for more than two decades. Reforestation, oyster reef restoration, nutrient banking, and other nature-based solutions do not happen overnight. They require planning, teamwork, patient capital, scientific measurement, and long-term stewardship.

Playbook for the Planet brings these two stories together.

"Resilience is not built in the moment it gets tested. It is built long before anyone is watching," said Haley Van Voorhis. "As athletes, we depend on the air we breathe, the water we drink, and the outdoor places where we train, compete, and recover. Caring for those systems is part of caring for ourselves and the generations that come after us."

The campaign draws a connection between the environments that support human performance and the natural systems that sustain communities. Clean air, healthy soil, functioning waterways, forests, and coastlines are not distant environmental concepts. They are part of the places where people live, work, play, and recover.

For ACRE, that connection is grounded in years of work alongside landowners, foresters, scientists, conservation professionals, and community partners. Across the Mississippi Alluvial Valley, the Carolina Piedmont, and the Chesapeake Bay region, ACRE and its platforms have helped build the financial and operational infrastructure needed to restore nature at scale.

ACRE's work includes GreenTrees, a reforestation program covering more than 140,000 acres of privately owned land across approximately 650 landowner partners; Conservation+, a Virginia nutrient bank developer; Oyster Carbon Company, which advances oyster reef restoration in the Chesapeake Bay; and Big River Nursery, a producer of Eastern Cottonwood planting stock. Together, these efforts reflect a broader vision of natural capital that recognizes the interconnected value of air, land, and water.

"The trees, reefs, and restored landscapes are what people see, but every project begins with people," said Marcia Degnan, Chief Marketing Officer of ACRE Investment Management. "Behind the work are landowners making long-term decisions about their property, scientists measuring outcomes, nurseries growing the next generation of forests, and partners willing to invest in restoration. Playbook for the Planet is about telling that larger story and showing that the health of people and the health of the places around them are intertwined."

Rather than presenting conservation as something removed from daily life, Playbook for the Planet invites people to see themselves as participants. The choices made today about forests, waterways, coastlines, and working lands will shape the places where future generations live and play.

The campaign will share stories from athletes, landowners, restoration professionals, and others whose work demonstrates what long-term resilience looks like in practice. More information is available at acre-investment.com/playbook-for-the-planet.

About ACRE Investment Management

ACRE Investment Management, LLC is a natural capital company managing five platforms across carbon removal, reforestation, nutrient mitigation, and ecosystem restoration. ACRE works with private landowners, corporate buyers, investors, and government agencies to make large-scale restoration economically achievable. Follow on LinkedIn at https://www.linkedin.com/company/acre-investment-management.

About Haley Van Voorhis

Haley Van Voorhis is a former Shenandoah University football safety who made NCAA history in September 2023, recording a quarterback hurry that garnered international attention and led to her jersey and helmet being included in the NCAA College Football Hall of Fame. A multi-sport athlete, she also played for the D.C. Divas of the Women's Football Alliance. As the featured voice of Playbook for the Planet, Van Voorhis brings her commitment to preparation, perseverance, and resilience to the connection between human and planetary health.

Media Contact

Randy Williams

[email protected]

(917) 213-5980

SOURCE ACRE Investment Management

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Cell Stem Cell: Die tBE-vermittelte Base-Editing-Therapie erzielt bei unterschiedlichen genetischen Hintergründen eine dauerhafte klinische Remission bei Sichelzellkrankheit und β-Thalassämie

Nachdem bei chinesischen TDT-Patienten eine 100-prozentige Transfusionsunabhängigkeit erreicht wurde, bestätigt eine neue Studie, dass tBE für afrikanische SCD-Patienten sowie für TDT-Patienten aus Süd- und Südostasien ebenso sicher und wirksam ist.

SHANGHAI, 8. September 2026 /PRNewswire/ -- Am 7. September 2026 veröffentlichte Cell Stem Cell in Shanghai online eine klinische Forschungsarbeit von CorrectSequence Therapeutics (Correctseq), die in Zusammenarbeit mit mehreren Institutionen entstand, unter dem Titel „Clinical base editing for β-hemoglobinopathies across different genetic backgrounds" („Klinisches Base Editing bei β-Hämoglobinopathien mit unterschiedlichen genetischen Hintergründen"), wobei gezeigt wurde, dass CS-101/CS-206 – eine mit dem transformer Base Editor (tBE) entwickelte Base-Editing-Therapie – bei Patienten mit β-Hämoglobinopathien unterschiedlicher genetischer Herkunft eine gleichbleibende Wirksamkeit und Sicherheit erzielte. Dies knüpft an den früheren klinischen Bericht des Teams über fünf chinesische Patienten mit transfusionsabhängiger β-Thalassämie (TDT) an, die mit CS-101 behandelt wurden und alle die Transfusionsunabhängigkeit erreichten (Lai et al, Nature, 2026). Die neue Studie weitet die Behandlung auf vier weitere Patienten aus Nigeria, Laos, Malaysia und Pakistan aus – einen mit Sichelzellkrankheit (SCD) und drei mit TDT. Alle erreichten eine rasche hämatopoetische Rekonstitution, eine anhaltend hohe panzelluläre HbF-Expression, vollständige Transfusionsunabhängigkeit oder Freiheit von vaso-okklusiven Krisen (VOCs), ohne nachweisbare Off-Target-Edits oder produktbedingte unerwünschte Ereignisse.

Breite Anwendbarkeit bei verschiedenen ethnischen Gruppen und Mutationen

β-Hämoglobinopathien gehören zu den häufigsten monogenen Erkrankungen; weltweit sind jährlich über 300 000 Neugeborene von SCD und über 40 000 von TDT betroffen. Pathogene Mutationen variieren erheblich zwischen den Populationen. Das Team hatte zuvor den ultrapräzisen tBE (Wang et al., Nat Cell Biol, 2021) entwickelt, um die HBG1/2-Promotorregion in autologen, den Patienten entnommenen HSPCs präzise zu editieren und so die γ-Globin-Expression wieder zu aktivieren. Die Genotypen der vier Patienten in der vorliegenden Studie umfassten βS/βS bei SCD sowie drei TDT-Genotypen – β⁰/βᴱ, β⁰/β⁰ mit einer großen Deletion und β⁰/β⁰ mit einer Einzelnukleotid-Insertion –, was die universelle Anwendbarkeit der Strategie bestätigt.

Klinische Daten: Rasches Engraftment, anhaltendes Ansprechen, vollständige Transfusionsunabhängigkeit und keine Off-Target-Mutationen

Bei der 21-jährigen SCD-Patientin aus Nigeria, bei der im Jahr vor dem Studieneinschluss mehr als vier VOCs aufgetreten waren, wurde das Neutrophilen-Engraftment an Tag 13 und das Thrombozyten-Engraftment an Tag 21 nach der Infusion erreicht. Der Gesamt-Hämoglobinspiegel stieg von 7,7 g/dl zu Studienbeginn auf 12,9 g/dl im dritten Monat an und blieb über 11 g/dl; der HbF-Spiegel stieg von 3,5 % auf 62,2 %, während der HbS-Spiegel von 76,1 % auf 31,6 % sank und sich bei einem Verhältnis von etwa 6:4 stabilisierte. Nach einer Nachbeobachtungszeit von 15,5 Monaten traten keine VOCs auf.

Bei den drei TDT-Patienten (im Alter von 3 bis 29 Jahren, aus Laos, Malaysia und Pakistan) wurde nach 13 Tagen das mediane Neutrophilen-Engraftment und nach 27 Tagen das mediane Thrombozyten-Engraftment erreicht. Die mittlere Gesamt-Hämoglobinkonzentration lag bei 11,6 ± 1,2 g/dl, und die mittlere HbF-Konzentration stieg im dritten Monat auf 9,8 g/dl an. Nach einer medianen Nachbeobachtungszeit von 17,5 Monaten hatten alle Patienten eine dauerhafte Transfusionsunabhängigkeit erreicht. Es wurden keine Off-Target-Veränderungen oder produktbedingten unerwünschten Ereignisse festgestellt.

Vergleich mit nukleasebasierten Gen-Editing-Therapien: Schnelleres Engraftment, höhere Expression, höhere Sicherheit

In klinischen Studien zur SCD erzielte tBE ein überlegenes Neutrophilen-Engraftment (13 Tage) gegenüber Cas9 (27 Tage) und Cas12a (23 Tage) sowie ein überlegenes Thrombozyten-Engraftment (21 Tage) gegenüber Cas9 (35 Tage) und Cas12a (25 Tage). tBE hielt einen HbF-Anteil von >60 % des gesamten Hämoglobins aufrecht und übertraf damit die Cas9- und Cas12a-Behandlungsschemata (50 %) deutlich.

Im Gegensatz zu Nukleasen, die auf DNA-Doppelstrangbrüche (DSBs) angewiesen sind, ermöglicht tBE eine präzise Basenumwandlung, ohne die DNA zu spalten, wodurch die Aktivierung von p53, Apoptose, große Deletionen und chromosomale Umlagerungen vermieden werden. Sein duales gRNA- und „Schlüssel-Schloss"-Design minimiert das Risiko von Off-Target-Effekten zusätzlich. Durch ein spaltbares „Schloss" wird tBE nur an den Zielstellen aktiviert, wodurch eine hocheffiziente Editierung bewirkt wird. Bei der Bindung an Off-Target-Stellen blieb tBE „gesperrt", um Off-Target-Mutationen zu vermeiden.

Weltweite Fortschritte und regulatorischer Zulassungsweg

Bislang wurden mit CS-101 und CS-206 mehr als 30 Patienten in China, Afrika, Südostasien und Südasien behandelt, wobei 100 % der Patienten Transfusionsunabhängigkeit erreichten oder frei von VOCs blieben und eine anhaltend hohe Hämoglobinexpression aufwiesen. CS-101, der weltweit erste in klinischer Entwicklung befindliche Base-Editing-Therapiekandidat, dessen erster Patient im Oktober 2023 behandelt wurde, hat Phase I abgeschlossen und wird derzeit in zulassungsrelevanten Studien untersucht. Alle in Phase I behandelten Patienten sind seit mehr als einem Jahr transfusionsunabhängig, wobei die längste Dauer fast drei Jahre beträgt.

Professor Chen Jia, Gründer von Correctseq und Direktor des Gene Editing Center an der ShanghaiTech University, erklärte: „Dieser Artikel in Cell Stem Cell bestätigt die breite Anwendbarkeit von tBE bei unterschiedlichen genetischen Hintergründen und schließt damit den Weg von der Laborforschung zur weltweiten klinischen Anwendung ab. Unser Team befasst sich außerdem mit RNA-Editing, Prime-Editing und mitochondrialem DNA-Editing für andere Therapiebereiche."

Dr. Mou Xiaodun, Geschäftsführer von Correctseq, fügte hinzu: „Die Daten belegen, dass tBE eine weltweit führende Plattform ist. Darüber hinaus erweitern wir unser Tätigkeitsfeld auf Stoffwechsel- und Herz-Kreislauf-Erkrankungen, darunter Hypertriglyceridämie/familiäres Chylomikronämie-Syndrom (FCS), ASCVD/Hyperlipoproteinämie, homozygote familiäre Hypercholesterinämie (HoFH) sowie Metabolische Dysfunktion-assoziierte Steatohepatitis (MASH). Wir treiben mehrere Entwicklungsprojekte voran, um weltweit IND-Anträge einzureichen und so die in China entwickelte Geneditierung mehr Patienten weltweit zugänglich zu machen."

Link zum Artikel in Cell Stem Cell: https://doi.org/10.1016/j.stem.2026.08.009

Informationen zu CorrectSequence Therapeutics

CorrectSequence Therapeutics (Correctseq) ist ein Biotechnologieunternehmen in der klinischen Entwicklungsphase, das seinen firmeneigenen „transformer Base Editor (tBE)" einsetzt, um wegweisende Gen-Editierungs-Therapien der nächsten Generation zu entwickeln. Das Unternehmen hat mehrere hochmoderne Base-Editing-Systeme entwickelt, die außergewöhnliche Präzision bieten, Off-Target-Effekte minimieren und die Editierungseffizienz ex vivo und in vivo verbessern. Die umfangreiche Pipeline des Unternehmens umfasst genetische Erkrankungen, Stoffwechselerkrankungen und Herz-Kreislauf-Erkrankungen, wobei sich mehrere Programme bereits auf dem Weg in die klinische Entwicklung befinden.

Weitere Informationen finden Sie auf www.correctsequence.com.

Danksagungen: The First Affiliated Hospital of Guangxi Medical University, ShanghaiTech University, Children's Hospital of Fudan University, Institutes of Biomedical Sciences, Fudan University, Shanghai Clinical Research and Trial Center.

Medienkontakt:

Geschäftliche Zusammenarbeit: [email protected]

Rekrutierung für klinische Studien: [email protected]

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Disruptive Science, AI, and Innovation Forum at Clinton Presidential Center

Free Admission to Learn About Prevention, Transplants, and Treatments

WASHINGTON, Sept. 8, 2026 /PRNewswire/ -- The American Association of Kidney Patients (AAKP), the nation's oldest and largest fully independent kidney patient advocacy organization, will host its 51st annual National Patient Meeting September 10 – 13, 2026, in Little Rock, Arkansas. Event admission and meals are free to kidney patients, family members/care partners, and living organ donors; pre-registration is encouraged and can be completed online at https://bit.ly/AAKPNPM or by calling (800) 749-2257.

In 2011, AAKP hosted a ground-breaking policy forum at the William J. Clinton Presidential Center that highlighted the direct link between outdated, status quo kidney dialysis care and patient unemployment. This marked the first time a national kidney group had targeted increased medical innovation and policy advocacy specifically as a strategy for ending economic dependency and increasing patient survival.

The 2026 AAKP National Patient Meeting is the premier in-person and online kidney patient and care partner event and a key element of AAKP's Decade of the Kidney™ initiative. More than 30 expert speakers are involved in the 2026 Little Rock program including kidney professionals, healthcare and policy influencers, advocacy skill trainers, innovation leaders from pharmaceutical, device, and diagnostic companies, and nonprofit executives. The meeting follows AAKP's successful All Kidney Policy is Local™ national campaign which connected patients, organ donors, and caregivers to U.S. Congressional leaders in their home district offices and online during the Congressional summer recess. The campaign has resulted in over 300 targeted legislative and policy meetings with top Congressional decision-makers since 2025.

Featured experts from the University of Arkansas for Medical Sciences (UAMS) include Dr. John M. Arthur, Chief, Nephrology Division; Director, Translational Research Institute; and Director, Junior Faculty Mentored Research Program, Department of Internal Medicine, UAMS; Dr. Brandi P. Wright, Nephrologist, Jefferson Regional Medical Center; Medical Director, Lifepoint Health Systems; Associate Professor, UAMS; Dr. Manisha Singh, Professor; Director, Home Dialysis, UAMS and VA Little Rock; Co-Director Renal Module, Division of Nephrology, Department of Internal Medicine, UAMS, and Joy Cope, MSN, MBA-HC, RN; Nursing Director & Administrator, Solid Organ Transplant Program, UAMS.

Dr. Arthur will speak on Cardio Kidney Metabolic (CKM) Syndrome; Dr. Wright will speak on Cardio Kidney Metabolic (CKM) lab values; Dr. Singh will speak on rare kidney diseases; and Ms. Cope will discuss how kidney patients maintain transplant readiness and eligibility. They are joined by internationally recognized known science leaders and clinicians Dr. Dominic Raj, the Bert B. Brooks Chair in the School of Medicine, Professor of Medicine, Biochemistry and Genetics and Biostatistics and Epidemiology and Director of the Division of Renal Disease and Hypertension at the George Washington University School of Medicine and Health Sciences (GW SMHS) and Dr. Prabir Roy-Chaudhury, the Drs. Ronald and Katherine Falk Eminent Professor in Nephrology and the Co-Director of the Kidney Center at the University of North Carolina (UNC). Drs. Raj and Roy-Chaudhury will discuss rapidly evolving kidney science and new, transformative kidney care innovations.

The AAKP National Patient Meeting begins Thursday, September 10, with AAKP's Public Policy Forum at the William J. Clinton Presidential Center from 1:00 p.m. – 4:00 p.m. CT. This complimentary, in-person event will highlight kidney research and innovation and the impact of federal regulatory and reimbursement decisions. Doors open at 12:00 p.m. CT with lunch provided. Registration is required, please click here to reserve your spot.

The National Patient Meeting continues September 11 – 13 at the Little Rock Marriott. Click here for virtual registration, and here for in-person registration.

Who: The American Association of Kidney Patients (AAKP)

What: The 51st Annual National Patient Meeting

When: September 10-13, 2026

Where: Public Policy Forum, September 10th from 1:00 p.m. – 4:00 p.m. CT at the Clinton Presidential Library (free registration, complimentary lunch provided); National Kidney Patient Meeting, September 11 – 13 at the Little Rock Marriott, Little Rock, Arkansas, and virtually (free registration for virtual and in-person attendees, complimentary meals provided to in-person attendees)

Follow AAKP on social at @kidneypatient on Facebook, @kidneypatients on X, and @kidneypatients on Instagram. Visit http://www.aakp.org for more information on AAKP patient leadership and kidney care.

MEDIA CONTACT:

Brendan LaCivita

National and Medical Media Specialist

[email protected]

(813) 906-7740

SOURCE American Association of Kidney Patients

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